The Incompatible Time Sharing System (ITS) was developed at the MassachusettsInstituteOfTechnology's AI Lab (http://ai.mit.edu/) in the late 1960s. It was written in AssemblyLanguage and ran on DigitalEquipmentCorporation's PDP-10s at MIT until 1990, and then until 1995 at the Stacken Computer Club in Sweden.
Despite its small user base, it has had immense influence due to the software originally developed for it. This includes: